News and Events

12/1/2008

Researchers Use Affymetrix Technology to Discover Why Some Breast Cancer Patients Resist Tamoxifen

11/26/2008

Affymetrix to Webcast Presentation at Piper Jaffray Healthcare Conference

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Molecular Biology Society of Japan & Japanese Biochemical Society

12/09/2008-12/12/2008

Society of Biological Chemists (India) SBC, IITM

12/18/2008-12/20/2008

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Scientific Publications

Search our database of 15655 publications.

GeneChip^® Rat ToxFX 1.0 Array

The GeneChip® Rat ToxFX 1.0 Array consists of a single array containing 2,073 probes sets that represent 55 signatures and 22 pathways of direct toxicological interest. Analysis of the microarray data is fully automated through the ToxFX™ Study Builder software and ToxFX™ Analysis Engine, providing exhaustive documentation of the toxicological and pharmacological profile of the drug candidate or compound of interest in an easy-to-read report. ToxFx 1.0 comes with a ToxFX Certificate of Analysis that allows you to generate a full toxicology report.

For more information, please visit www.toxfx.com.

Rat ToxFX 1.0 Array

Figure 3, Table 1

The Rat ToxFX 1.0 Array comprises a focused subset of content present on the whole-genome Rat Genome 230 2.0 Array; the subset of probes represent genes associated with Drug Signatures® and pathways present in Entelos' DrugMatrix® library (previously Iconix Biosciences).

All probe sets on the Rat ToxFX 1.0 Array are identical to their counterparts on the Rat Genome 230 2.0 Array; the focused array also includes the same hybridization, sample labeling and housekeeping controls. For a full comparison of features, please refer to the Rat ToxFX 1.0 datasheet or view, Figure 3 and Table 1.

Eleven pairs of oligonucleotide probes are used to measure the level of transcription of each gene sequence interrogated by the Rat ToxFX 1.0 Array. The oligonucleotide probes are synthesized in situ using Affymetrix' photolithograthic process, in an identical manufacturing process as the GeneChip® Rat Genome 230 2.0 Array.

ToxFX™ Report

The ToxFX Report is automatically generated as a PDF document and provides an in-depth summary of all aspects of the toxicology study and its results. Data are summarized at a variety of levels, from executive summary to in depth pathway analysis. For more information, please visit www.toxfx.com.

To request a sample ToxFX report, please contact us.

Sections of the report include:

Executive Summary — Single-page summary highlighting key safety issues
Study Description — Detailed record of study design
Drug Signatures — Report on potential safety liabilities based on toxicological matches correlating with more than 50 biological endpoints (e.g., cholestasis, hepatic duct hyperplasia)
Pathways — Detailed analysis and diagrams indicating treatment impact on 22 molecular pathways of key toxicological interest (e.g., bile acid and cholesterol metabolism or oxidative stress)
Toxicologically Relevant Gene Groupings — A single table comprising expression data from noteworthy genes of toxicological interest (e.g., cytochrome P450)
Methodology and Glossary — Documentation of the analytical approaches and terms required to interpret results

Data Sheets

ToxFX™ Analysis Suite (pdf, 234 KB)

GeneChip^® Rat ToxFX 1.0 Array (Including the ToxFX Analysis Report)

Part #	Description	Details
900994	GeneChip® Rat ToxFX 1.0 Array	Contains 2 Rat ToxFX 1.0 Arrays
900995	GeneChip® Rat ToxFX 1.0 Array	Contains 6 Rat ToxFX 1.0 Arrays
900996	GeneChip® Rat ToxFX 1.0 Array	Contains 30 Rat Tox FX 1.0 Arrays
900997†	GeneChip® Rat ToxFX 1.0 Array with Reagents	† Contains 30 Arrays and GeneChip® One-Cycle Target Labeling and Control Reagents sufficient for 30 reactions.
	† The GeneChip® Hybridization, Wash and Stain Kit is not included and must be purchased separately.

Required Products

Part #	Description	Details
900493	GeneChip® One-Cycle Target Labeling and Controls Kit	The One-Cycle Target Labeling and Control Reagent package provides all necessary labeling and control reagents with one convenient part number.
00-0185 00-0186	GeneChip® Scanner 3000	Provides GeneChip® Microarray scanning. See Product Page.
00-0079	GeneChip® Fluidics Station 450	The GeneChip® Fluidics Station 450 provides easy to use staining and washing of microarrays.
800138 800139	GeneChip® Hybridization Oven 640	The Hybridization Oven 640 delivers precise temperature control allowing consistent hybridization performance. See Product Page.
690036	GeneChip® Operating Software v1.4 or higher	Available Via Download
	Expression Console™ Software	Available Via Download
	ToxFX™ Study Builder	Available via ToxFx Website

Related Products

Part #	Description	Details
	Assays and Reagents	See Product Page

FAQs

Gene Expression Arrays

Rat ToxFX 1.0 Array

Manuals

3' IVT Express Kit User Manual (pdf, 3.47 MB)

Expression Analysis Technical Manual, with Specific Protocols for Use with the Hybridization, Wash, and Stain Kit (pdf, 2.1 MB)

Probe Set Data in MAGE-ML Format

ToxFX™ Analysis Suite Manual (pdf, 1.0 MB)

Library Files

Rat ToxFX 1.0 Array (zip, 3.26 MB)

ToxFX Gene List (zip, 170KB)

Package Inserts

Rat ToxFX 1.0 Array (pdf, 212 KB)

Alignment, Annotation, and Sequence Files

Information about using Alignment, Annotation, and Sequence files

Current NetAffx Annotation Files

RatToxFX Annotations, CSV format (832 KB, 11/30/08)

RatToxFX Annotations, MAGE-ML XML Format (3.6 MB, 11/24/08)

RatToxFX BLASTP annotations, CSV Format (3.4 KB, 11/24/08)

RatToxFX Orthologs/Homologs, CSV Format (518 KB, 11/24/08)

Note: NetAffx annotation files are intended for use in automated analysis. Some are not compatible with all spreadsheet applications. Please use the NetAffx Analysis Center to limit download data to your probe sets of interest. Annotation CSV files for the exon arrays are split into a probe set-level annotation file and a transcript cluster-level annotation file; exon array CSV files are compatible with ExACT.